2019騫?/span>6鏈?/span>24鏃ワ紝緇嗚優鐢熺墿瀛﹁憲鍚嶆湡鍒?/span>The Journal of Cell Biology浠?/span>Article褰㈠紡鍦ㄧ嚎鍙戣〃浜嗕簯鍗楀ぇ瀛︾敓鍛界瀛︿腑蹇?/span>/鐢熷懡縐戝瀛﹂櫌鏉ㄥ磭鏋楀疄楠屽鐨勭爺絀惰鏂?/span>鈥?/span>姘ㄥ熀閰歌漿榪愯泲鐧?/span>SLC-36.1鍗忓悓紓瘋剛閰拌倢閱?/span>-3紓烽吀嬋€閰惰皟鎺у悶鍣憾閰朵綋鐨勫啀褰㈡垚鈥?/span>錛?/span>The amino acid transporter SLC-36.1 cooperates with PtdIns3P 5-kinase to control phagocytic lysosome reformation錛夈€?/span>
婧墮叾浣撴槸緇嗚優涓噸瑕佺殑緇嗚優鍣紝鍏鋒湁鐢熺墿闄嶈В銆佷唬璋㈢ǔ鎬佺淮鎸併€佸垎娉屻€佽惀鍏諱俊鍙鋒劅鐭ュ強浼犻€掔瓑鍔熻兘銆傛憾閰朵綋鍔熻兘澶辮皟浼氬鑷翠弗閲嶇殑浜虹被鐤劇梾錛屽婧墮叾浣撹串縐棁鍜岀緇忛€€琛屾€х柧鐥呯瓑銆傛潵鑷唴鍚炰綔鐢ㄣ€佸悶鍣綔鐢ㄥ拰鑷櫖鐨勮揣鐗╅兘浼氳榪愰€佸埌婧墮叾浣擄紝闅忓悗榪欎簺璐х墿浼氬湪鍐呭悶婧墮叾浣撱€佸悶鍣憾閰朵綋鍜岃嚜鍣憾閰朵綋涓殑閰告€ф按瑙ｉ叾鐨勪綔鐢ㄤ笅琚檷瑙ｃ€傜劧鑰岋紝鎴戜滑瀵硅揣鐗╄闄嶈В涔嬪悗錛屾憾閰朵綋浠庡唴鍚炴憾閰朵綋銆佸悶鍣憾閰朵綋鍜岃嚜鍣憾閰朵綋涓婂啀褰㈡垚鐨勮繃紼嬪拰璋冩帶鏈哄埗鍗寸煡涔嬬敋灝戙€?/span>鏉ㄥ磭鏋楀疄楠屽浠ョ涓界嚎铏負妯″紡銆佷互鍚炲櫖婧墮叾浣撲負紿佺牬鍙ｏ紝緇忚繃澶氬勾鎺㈢儲錛屾彮紺轟簡鍚炲櫖婧墮叾浣撳啀褰㈡垚鐨勮繃紼嬪拰璋冩帶鏈哄埗銆?/span>
縐€涓界嚎铏槸鐮旂┒緇嗚優鍑嬩骸鐨勭悊鎯沖疄楠屾潗鏂欙紝鍦ㄥ井鍒嗗共娑夋樉寰暅涓嬶紝綰胯櫕鑳氳儙緇嗚優鍙戠敓鍑嬩骸鍚庡憟鐜板嚭鐗規畩鐨勭航鎵ｇ姸紿佽搗褰㈡€併€傛潹宕囨灄瀹為獙瀹ら€氳繃姝ｅ悜閬椾紶瀛︾瓫閫夛紝鑾峰緱浜嗗涓噵浜＄粏鑳炲憟鍑瑰潙鐘剁殑紿佸彉浣擄紝緇忓厠闅嗗彂鐜版槸鐢變簬slc-36.1鍩哄洜鍔熻兘緙哄け紿佸彉瀵艱嚧銆?/span>SLC-36.1铔嬬櫧鍦ㄤ漢綾諱腑鐨勫悓婧愮墿鏄腑鎬ф皚鍩洪吀杞繍铔嬬櫧SLC-36A1銆?/span>SLC-36.1瀹氫綅鍦ㄧ粏鑳炶川鑶滃拰婧墮叾浣撹啘涓婏紝鑰屼笖瀹冪殑姘ㄥ熀閰歌漿榪愭椿鎬у浜庡叾鍔熻兘鏄繀欏葷殑銆傜爺絀惰€呯敤緇胯壊鑽у厜铔嬬櫧鏍囪婧墮叾浣撹啘铔嬬櫧LAAT-1錛岀敤綰㈣壊鑽у厜铔嬬櫧鏍囪婧墮叾浣撳熀璐ㄨ泲鐧?/span>NUC-1錛屽湪鑽у厜鏄懼井闀滆拷韙憾閰朵綋鍦ㄧ敓鐞嗘潯浠朵笅鐨勫彉鍖栬繃紼嬨€傚湪閲庣敓鍨嬬嚎铏殑鑳氳儙涓紝闅忕潃鍚炲櫖婧墮叾浣撲笉鏂幾鍑轟笣鐘剁粨鏋勶紝騫舵樉紺烘湁鏂扮殑婧墮叾浣撲駭鐢燂紝鑰屽悶鍣憾閰朵綋鐨勪綋縐笉鏂緝灝忓茍鏈€緇堟秷澶便€備絾鏄紝鍦?/span>slc-36.1紿佸彉浣撶殑鑳氳儙涓紝鍚炲櫖婧墮叾浣撳嚭涓濈殑嬈℃暟鏄庢樉鍑忓皯錛屽茍涓斿悶鍣憾閰朵綋鐨勪綋縐湪寰堥暱鏃墮棿鍐呴兘淇濇寔涓嶅彉錛堜笅鍥撅級銆傚洜姝わ紝SLC-36.1瀵逛簬婧墮叾浣撲粠鍚炲櫖婧墮叾浣撲笂鍐嶅艦鎴愮殑榪囩▼鏄繀闇€鐨勩€?/span>
璇ョ爺絀惰繕鍙戠幇PPK-3鍔熻兘緙哄け鍚屾牱浼氶樆紕嶆憾閰朵綋浠庡悶鍣憾閰朵綋涓婂啀褰㈡垚銆?/span>PPK-3鏄?/span>紓瘋剛閰拌倢閱?/span>-3紓烽吀嬋€閰訛紝鑳藉鍌寲紓瘋剛閰拌倢閱?/span>-3-紓烽吀緇х畫紓烽吀鍖栵紝鐢熸垚紓瘋剛閰拌倢閱?/span>-3錛?/span>5-浜岀７閰革紝宸茬煡紓瘋剛閰拌倢閱?/span>-3錛?/span>5-浜岀７閰稿浜庤啘鍒嗚璧風潃閲嶈浣滅敤銆?/span>榪涗竴姝ョ殑鐮旂┒琛ㄦ槑錛?/span>SLC-36.1鐩存帴涓?/span>PPK-3鐩鎬簰浣滅敤錛屽艦鎴愬鍚堜綋錛屽崗鍚屼綔鐢ㄥ彂鎸ヨ皟鎺т綔鐢ㄣ€?/span>鐮旂┒榪樺彂鐜幫紝鍦ㄦ憾閰朵綋浠庤嚜鍣憾閰朵綋涓婂啀褰㈡垚鐨勮繃紼嬩腑錛?/span>SLC-36.1-PPK-3澶嶅悎鐗╀篃鍙戞尌浜嗚皟鎺т綔鐢ㄣ€?/span>
鏈」鐮旂┒闃愭槑浜?/span>SLC-36.1-PPK-3澶嶅悎鐗╁湪鍚炲櫖婧墮叾浣撴垨鑷櫖婧墮叾浣撲笂婧墮叾浣撳啀褰㈡垚鐨勮繃紼嬩腑璧峰埌浜嗚嚦鍏抽噸瑕佺殑璋冩帶浣滅敤銆?/span>
浜戝崡澶у鐪侀儴鍏卞緩浜戝崡鐢熺墿璧勬簮淇濇姢涓庡埄鐢ㄥ浗瀹墮噸鐐瑰疄楠屽銆佺敓鍛界瀛︿腑蹇冧互鍙婄敓鍛界瀛﹀闄負鏈爺絀剁殑絎竴鍗曚綅錛屾潹宕囨灄瀹為獙瀹ょ殑鐢樺惎鏂囧崥澹負鏈枃絎竴浣滆€咃紝鏉ㄥ磭鏋楁暀鎺堜負閫氳浣滆€呫€傝鐮旂┒鑾峰浗瀹惰嚜鐒跺熀閲戝鍛樹細閲嶇偣欏圭洰 (31730053) 鍜岀鎶€閮ㄩ噸鐐圭爺鍙戣鍒?/span>(2017YFA0503403)鐨勮祫鍔┿€?/span>
