2012騫?/span>10鏈?/span>23鏃?/span>錛?/span>鎴戞牎鐢熷懡縐戝瀛﹂櫌淇炴搗鑿佸壇鏁欐巿涓庝腑鍥界瀛﹂櫌涓婃搗鐢熷懡縐戝鐮旂┒闄㈠鐮旂┒鎵€銆佷腑縐戦櫌鐮旂┒鐢熼櫌銆佽嫳鍥?/span>Edinburgh澶у銆佷腑縐戦櫌鏄嗘槑鍔ㄧ墿鐮旂┒鎵€鍜屽痙鍥?/span>Max-Planck榪涘寲鍙ょ敓鐗╁鐮旂┒鎵€鐨勭爺絀朵漢鍛樺悎浣滐紝鍦?/span>Nature瀛愬垔Nature Communications鍙戣〃浜嗛涓?/span>鈥淓volution of the human-specific microRNA miR鐨勭鐮旇鏂囥€傝鏂囨彮紺轟簡涓€縐嶄漢綾葷壒鏈夌殑microRNA鍩哄洜 miR-941鍦ㄤ漢綾昏繘鍖栦腑鎵€璧風殑浣滅敤銆?/span>
浜虹被鐗規湁鍩哄洜鍦ㄤ漢綾葷墿縐嶅艦鎴愬拰浜虹被鐗規湁鎬у緛渚嬪鍙戣揪鐨勪漢綾誨ぇ鑴戙€佹瘺鍙戠殑閫€鍖栥€佺洿绔嬭璧般€佸鏉傜殑璇█絳夌殑褰㈡垚涓彂鎸ラ噸瑕佷綔鐢ㄣ€傝鐮旂┒璇佸疄miR-941鍩哄洜鍦?/span>100-600涓囧勾鍓嶅湪浜虹被榪涘寲鏋濅腑鍑虹幇錛岃搗婧愪簬涓€孌靛湪鐜頒唬浜虹兢浣撲腑鍛堢幇澶氭€佹€х殑涓茶仈閲嶅搴忓垪銆?/span>miR-941鍑虹幇浼撮殢miR-941緇撳悎浣嶇偣鐨勫姞閫熸紨鍙橈紝浠庤€屼嬌緇嗚優閫傚簲鏂板熀鍥犱駭鐢熷悗甯︽潵鐨勫姛鑳界綉緇滄敼鍙樸€傜爺絀舵樉紺?/span>miR-941鐨勫嚭鐜板獎鍝?/span>hedgehog鍜岃儼宀涚礌淇″彿閫氳礬鍩哄洜鐨勮〃杈撅紝鎻愮ず鍏跺湪淇″彿浼犲銆佺粏鑳炲垎鍖栦腑璧烽噸瑕佷綔鐢ㄣ€傝鐮旂┒鎻ず浜?/span>miR-941鍩哄洜榪涘寲涓嶅悓瀵誨父鐨勭壒鐐癸紝涓虹墿縐嶈繘鍖栦腑涓€涓柊杞綍鍚庤皟鎺у洜绱犱箖鑷崇綉緇滅殑蹇€熷嚭鐜版彁渚涜寖渚嬶紝瀹冪殑鍑虹幇鍙兘涓庝漢綾葷殑瀵垮懡鍜岃鐭ュ姛鑳藉瓨鍦ㄦ綔鍦ㄨ仈緋匯€傝鐮旂┒涓鴻繘涓€姝ラ槓鏄庝漢綾葷壒鏈夌殑閬椾紶鏈川鎻愪緵浜嗛噸瑕佷緷鎹€?/span>
淇炴搗鑿佸壇鏁欐巿涓庝腑縐戦櫌涓婃搗鐢熷懡縐戝鐮旂┒闄㈣綆楃敓鐗╁鐮旂┒鎵€鐨?/span>Philipp Khaitovich鐮旂┒鍛樺叡涓鴻繖綃囨枃绔犵殑閫氳浣滆€呫€備漢綾葷壒鏈夊熀鍥犵爺絀剁殑鎶ラ亾鐩墠榪樹負鏁頒笉澶氾紝miR-941鏄縿浠婇涓鐮旂┒鎶ラ亾鐨勪漢綾葷壒鏈?/span>microRNA鍩哄洜錛岃繖綃囪鏂囦篃鏄繛嫻瘋弫鍓暀鎺堢戶2006騫寸殑涓€涓漢綾葷壒鏈夎泲鐧借川緙栫爜鍩哄洜鐮旂┒鎶ラ亾錛?/span>Human Molecular Genetics 2006 15:1870-5錛夊悗鐨勫張涓€閲嶈鐮旂┒緇撴灉銆?/span>
縐戞妧澶?/span>
2012騫?/span>10鏈?/span>30鏃?span style="mso-spacerun: yes">
